Afflictions are enemy-applied penalties that attack your deck instead of your HP bar. They come in two forms: status cards injected into your draw pile, and debuffs that strip Strength, Dexterity, or prevent actions.

Alternate Acts are Slay the Spire 2's route-level branching system. Each act has two biome variants with distinct enemies, events, elites, and bosses. Act 1 is Overgrowth or Underdocks; Acts 2 and 3 have their own confirmed splits.

Doom is Necrobinder's signature kill threshold. When a target ends its turn with Doom stacks at or above current HP, it dies outright — ignoring Block, Metallicize, and low-HP boss triggers.

Sly is Silent's defining keyword. A Sly card that you discard automatically plays for free, which turns discard into Silent's highest damage lever.

Stars are Regent's persistent secondary resource. They do not reset at turn end and they have no cap, which enables Regent's infinite Stars/Energy conversion builds.

Forge is Regent's delayed-payoff archetype. The first Forge each combat creates a Retain colorless attack called Sovereign Blade, and every later Forge stack increases that blade's damage.