Should I ever take Ectoplasm?
Almost never. Ectoplasm's +1 Energy is powerful, but permanently losing all gold income means no card removal, no relic purchases, and no potions for the rest of the run. The only scenario where Ectoplasm is acceptable is when your deck is already finished, you have no planned shop visits remaining, and you specifically need +1 Energy to execute your game plan. This situation arises in fewer than 5% of runs.